Median PFS was 5 months and median survival was 31.6 months.Ĭonclusions: The safety and promising efficacy makes this combination worthy of future investigation in mCRPC. Primary endpoint of 6 month progression free survival (PFS) was achieved in 5 of 14 patients (38.5%, 95%CI 19.5%-76.5%). The toxicities were grade1-2 infusion reactions with fever, chills, headaches, nausea and/or myalgias.
All were pretreated with androgen receptor axis targeted agents and 7 (50%) had prior docetaxel chemotherapy. Two patients had peritoneal metastases, 1 had lymph node (LN) only metastases and 11 had bone metastases of which 7 had bone and LN metastases. Results: Fourteen patients were enrolled with a median age of 69 (range 57-82 years) and median PSA of 143.4 (range 8.2 – 4210 ng/dL). HER2 BATs were infused twice weekly for 4 weeks and pembrolizumab was administered every 21 days for a maximum duration of 6 months starting 1-3 weeks prior to HER2 BATs infusion. Peripheral blood mononuclear cells (PBMC) were obtained by a single apheresis, shipped to University of Virginia, activated with OKT3 and expanded for 14 days in IL-2, harvested, and armed with HER2Bi and cryopreserved. Primary endpoint was 6 month progression free survival. Patients and Methods: Metastatic castrate resistant prostate cancer (mCRPC) patients with 0-1 performance status (PS) and normal liver, kidney and marrow function, pre or post docetaxel chemotherapy were eligible. When done, click FINISH.Purpose: A phase II study was conducted to evaluate the safety and efficacy of the combination of HER2 BATs and programmed death -1 (PD-1) inhibitor, pembrolizumab. Choose the destination folder (usually in C:Program Files) and click NEXT.In the list of features, click on each red X and click "Entire feature will be installed on local hard drive." CUSTOM - will allow you to install all output styles, filters, and connection files (including ODU).Close all applications and turn off the background applications, including virus protection applications. Click 'Check For Updates', and download the latest update. Look for the 'Flash Player Installer' in the left pane of your screen. TYPICAL - will install the most commonly used output styles, filters, connection files. Open EndNote and select the Tools menu to access the Flash support features.Click NEXT through the info screens, and then select an Installation Type:.At the EndNote X8 Installation screen, click NEXT and ACCEPT.Then double-click the "ENX8Inst.msi" file (Windows Installer Package) to begin installation. In your Downloads folder, double-click the InstallEnX8 file folder.IMPORTANT STEP: Highlight the EndNote 20 folder, and " EXTRACT ALL FILES" Then exit the zip program.SAVE the file to DOWNLOADS or DESKTOP (or elsewhere), then OPEN.Click DOWNLOAD (message may say: No preview available), then DOWNLOAD ANYWAY.Quit Microsoft Word and all web browsers.Try the installation process again and make sure to Extract All Files in Step 4. NOTE: If you are asked for a product key or 30-day trial, the install process didn't recognize you as an ODU user.
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